Site Loader

Exanthematous drug eruptions. • «rashes». • Urticaria immediate reactions. • Delayed appearing exanthems with cell infiltration it is frequent. Therapy for exanthematous drug eruptions is supportive, involving the administration of oral antihistamines, topical steroids, and moisturizing. Morbilliform or exanthematous drug reaction (maculopapular drug eruption). Authoritative facts about the skin from DermNet New Zealand.

Author: Malajar Mulabar
Country: Montenegro
Language: English (Spanish)
Genre: Environment
Published (Last): 24 December 2009
Pages: 82
PDF File Size: 3.39 Mb
ePub File Size: 8.78 Mb
ISBN: 619-7-24190-311-4
Downloads: 85142
Price: Free* [*Free Regsitration Required]
Uploader: Akinogor

The patient should be made aware that pruritus and erythema may be severe. Other than this, systemic involvement is not a feature. See the DermNet NZ bookstore.

Morbilliform drug reaction

If the reaction is mild, and the drug is essential and not replaceable, obtain a specialist opinion whether it is safe to continue the drug exanthematkus doing so. Here Th 2 cells secrete interleukins 4, 13 and 5, which call eosinophils into the infiltrate, amongst other functions. Further investigations will depend on clinical features, progress of the patient, and the results of the initial tests.

drrug Here, the rash will get worse before it ultimately gets better and resolves. Morbilliform drug eruption is the most common form of drug eruption. This occurs secondary to hemostatic pressure that is typically maximal on the legs.

In the early phase, it may not be possible to clinically distinguish an uncomplicated morbilliform eruption from other more serious cutaneous adverse reactions SCAR.

In the dermis, there is a lymphocytic infiltrate with eosinophils. The history of upper respiratory tract symptoms and the presence of a lymphocytosis or lymhopenia on the white blood cell differential count as opposed to an eosinophilia point one towards eruptioj viral etiology. The onset of a morbilliform eruption MDE; also known as exanthematous or maculopapular drug eruption typically occurs within 7 to 10 days after the initiation of the culprit drug. Acute graft-versus host-disease GVHD.

A few apoptotic keratinocytes and focal parakeratosis may be found. Mid- or high potency topical steroids such as triamcinolone acetonide 0. Prescribers must be eruptkon.


It is mediated by cytotoxic T-cells and classified as a Type IV immune reaction. Which of the following best describes your experience with hand-foot-and-mouth disease?

Morbilliform Drug Eruptions (exanthematous drug eruption; maculopapular drug eruption, “drug rash”)

Inflammation follows the release of cytokines and other effector immune cells. They mainly affect people prescribed beta-lactam antibiotics penicillinscephalosporinssulfonamides, allopurinol, anti-epileptic drugs and nonsteroidal anti- inflammatory drugs NSAID. Morbilliform drug eruption [exanthematous drug eruption; maculopapular drug eruption, “drug rash” Are You Confident of the Diagnosis?

These patients are normally systemically ill with a fever. However, histopathologic specimens that are performed in cases where a differential diagnosis exists will show epidermal changes, including small areas of spongiosis, which may or may not arise above areas of vacuolar change of the basal layer. The offending agent should be discontinued if possible.

Patients may develop a peripheral eosinophilia in concert with MDE. Their incidence may be reduced by:. There may be vascular dilatation and mild edema in the upper dermis.

The eruption usually resolves within 7 to 14 days. Confluence and severity is worst in dependent areas, such as the back in hospitalized patients Figure 1. The eruption may resemble exanthems caused by viral and bacterial infections. Tests are not usually necessary if the cause has been identified and stopped, the rash is mild and the patient is well. Differential diagnosis includes measlesrubellascarlet fevernon-specific toxic erythema associated with infectionKawasaki diseaseconnective tissue disease and acute graft-versus-host disease.

As MDE resolves, it begins to look dusky and violaceous. Drugs can then be classified as unlikely or likely causes based on:. Morbilliform drug eruption is also called maculopapular drug eruptionexanthematous drug eruption and maculopapular exanthem. Morbilliform drug eruption usually first appears on the trunk and then spreads to the limbs and neck.

Morbilliform Drug Eruptions (exanthematous drug eruption; maculopapular drug eruption, “drug rash”)

The calendar must extend back at least 2 weeks and up to one month. Occasionally a day window has been noted. Bolognia, Joseph Jorizzo and Ronald Rapini. Toxin-mediated erythemas, such as toxic shock syndrome durg Strep toxic shock-like syndrome may present with an eruption that resembles MDE. Expected results of diagnostic studies The diagnosis is made based on the typical clinical appearance in concert with an appropriate drug history and the absence of systemic involvement.


If the causative drug drjg ceased, the rash begins to improve within 48 hours and clears within 1—2 weeks.

Diagnosis confirmation The following conditions should be considered in the differential diagnosis: No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC.

The eruption usually begins on the trunk and upper extremities and progresses caudally. Occasionally, duskiness may be seen in the resolving phases of MDE- here, the areas are not tender. In cases where the offending drug is not able to be discontinued, a discussion should be held regarding the risks and benefits of this, both with the dermatologist and the primary subspecialty team concerned. There are no routine tests to make the diagnosis or to identify the culprit drug.

Antiretroviral agents, such as the protease inhibitors, emtricitabine and tenofovir, and tealprevir for hepatitis C infection have also been reported to induce MDE. It is very rare for a drug that has been taken for months or years to cause a morbilliform drug eruption. The term “morbilliform” connotes a measles-like: A sandpaper-like eruption accompanies a sore throat and fever. Here, consultation with subspecialty teams is needed to assist in complex medication decisions.

However, this is not always seen. Often, however, these patients have been on multiple drugs, which complicate the clinical picture. The diagnosis is made based on the typical clinical appearance in concert with an appropriate drug history and the absence of systemic involvement.